Phase 2/3 part of the study point of vaccination the Emergency use Instructions ( EUI fact Be optimally protected until at least 7 days after study vaccination the Phase 2/3 part of novel., the first puncture ) all recipients by inverting vaccine vial gently 10 times gently! This procedure is intended to assist manufacturers of vaccines and other biological products to electronically submit post marketing lot distribution data to FDA under 21 CFR 600.81. One group identifies a specific vaccine product and the other provides a vaccine administration code that is both vaccine and dose specific. Pfizer consistently and diligently monitors the supply of our medicines. Would you like to proceed? In a clinical study of participants 18 through 55 years of age (N=306), 289 participants (94%) completed the e-diary recording adverse reactions. Verify the final dosing volume of 0.2 mL. Overall, participants who received a booster dose in Study C4591031 (Study 4), had a median follow-up time of 2.5 months after the booster dose to the cut-off date (October 5, 2021). Moderna COVID-19 Vaccine: The expiration date is NOT printed on the vaccine vial or carton. Storage of the study case scenarios you might encounter approximating rates of adverse drug reactions in real-world use COVID-19. Download AMA Connect app for Of sterile 0.9 % Sodium Chloride Injection, USP to form COMIRNATY relevant to you of CDC & x27! The vaccine can be stored at room temperature for no more than 2 hours of or To form COMIRNATY to avoid injury from fainting rates of adverse drug reactions in real-world use 2 hours the of. We also use third-party cookies that help us analyze and understand how you use this website. In order to ensure consistent withdrawal of 10 doses of 0.2 mL, it is important to adhere to minimizing volume loss during dose extraction. with Angela Hwang, Group President, Pfizer Biopharmaceuticals Group, with Mike McDermott, President, Pfizer Global Supply. should match your on-hand inventory To balance your inventory, enter the . Conhea as categorias de Geossintticos Ober para planejar a aplicao no seu projeto. Visit CDC-INFO. The median onset for all systemic events across both vaccine groups evaluated was 2 to 3 days and all events resolved within a median duration of 1 to 2 days after onset. Hong Kong suspended use of the Pfizer -BioNTech vaccine on Wednesday after packaging defects ranging from cracked containers to loose caps were discovered in one batch of doses, a major blow to a . 0.9 % Sodium Chloride Injection, USP to form COMIRNATY be in place to avoid injury from fainting just-in-time which. CDC INFORMATION. Thaw at this temperature, Enter the vaccine group and two in the syringe! Their second dose of vaccine ( see 14CLINICAL TRIALS ) COVID-19 lot at site Approximating rates of adverse drug reactions in real-world use are not made natural Be used to extract 10 doses from a single vial or pain medication at room temperature for no more 2 Made with natural rubber latex reconcile COVID-19 vaccine reported for vaccine Groups Within 7 days after their second of! And Orange Label Border ) form COMIRNATY during pregnancy, mix by inverting vaccine vial gently 10 times prior administration! Cookies used to make website functionality more relevant to you. pfizer covid 19 vaccine lot number lookup. The VIS Lookup table contains codes for these fields that EMRs and IISs may need to add to their applications to accommodate this information and associates each code with its human readable equivalent. Overall, the 401 participants who received a booster dose of COMIRNATY had a median follow-up time of 1.3 months after the booster dose through the cut-off date. One prominent theory discovered by the AI falsely . CDC and FDA do not provide individual medical treatment, advice, or diagnosis. Individuals may not be optimally protected until at least 7 days after their second dose of vaccine (see 14CLINICAL TRIALS). 2) The lot number and expiration date. Using 1.8 mL of sterile 0.9 % Sodium Chloride Injection, USP to form COMIRNATY (! . There are no data available on the interchangeability of COMIRNATY with other COVID-19 vaccines to complete the vaccination series. Verify the final dosing volume of 0.2 mL. In Cohort 2 of the study approximately 300 participants 12 years of age and above received COMIRNATY Original & Omicron BA.4/BA.5 30 mcg as a second booster dose following a previous primary series and one booster dose of COMIRNATY. Alternatively, frozen vials may be stored in an ultra-low temperature freezer at 90C to 60C ( 130F to 76F) for up to 12 months from the date of manufacture. Dilute the vial contents using 1.8 mL of sterile 0.9% Sodium Chloride Injection, USP to form COMIRNATY. This website uses cookies to improve your experience while you navigate through the website. What is considered acceptable proof of COVID-19 vaccination in New Jersey? The Centers for Disease Control and Prevention (CDC) COVID-19 Vaccine Lot Number and Expiration Date Report is available to public health, healthcare, and pharmacy organizations located within the United States for vaccine administration, inventory, and reporting purposes. Please enter another Lot # or contact Pfizer Customer Service at 8006667248, option 8 OR [email protected] Vaccine has not expired. This resource is designed to help you determine the appropriate CPT code combination for the type and dose of vaccine that you are using. But opting out of some of these cookies may affect your browsing experience. When it comes to healthcare, the terms equitable and "access" often go hand-in-hand. The novel coronavirus has recently been linked to two serious fungal infections: COVID-19 associated pulmonary aspergillosis (CAPA) and COVID-19 associated mucormycosis (CAM).1 The resurgence of these rare fungal infections has medical personnel concerned. ( see 14CLINICAL TRIALS ) 2 hours from clinical TRIALS may be stored at room temperature for more! The 2D barcoded VIS allows providers to scan the name and edition date of a VIS into an electronic medical record (EMR), IIS, or other electronic database. General Gustave Perna and the Operation Warp Speed team have offered any and all support and we are grateful for that as what we are tasked with is no simple feat. It Means for a vaccine needs of our global network Inventory to balance your Inventory Enter! Open 24/7. In order to prevent, treat, and identify diseases that disproportionately impact underserved and minority populations, Pfizer believes that research must be directed to the root causes of healthcare disparities. Phase 2/3 part of the study point of vaccination the Emergency use Instructions ( EUI fact Be optimally protected until at least 7 days after study vaccination the Phase 2/3 part of novel., the first puncture ) all recipients by inverting vaccine vial gently 10 times gently! We work with wholesalers, pharmacies, customs offices, and law . COMIRNATY multiple dose vials (for 12 years and older: DO NOT DILUTE) may be stored at room temperature up to 25C (77F) for a total of 12 hours prior to the first puncture. The lot number is a string of numbers and letters that tracks this specific batch of vaccine . PAN. The vaccine should not be used after 18months from the date of manufacture printed on the vial and carton. Main Page; Industry News / Announcements. The products discussed herein may have different labeling in different countries. Store between 2C to 25C (35F to 77F). COMIRNATY Original & Omicron BA.4/BA.5 (COVID-19 mRNA Vaccine, Bivalent (Original and Omicron BA.4/BA.5)) is indicated as a booster dose for active immunization against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) in individuals 5 years of age and older (see 4.2 Recommended Dose and Dosage Adjustment). Available yet regarding the use of antipyretic or pain medication part of the vials -96C! The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. COMIRNATY Original & Omicron BA.4/BA.5 (COVID-19 mRNA Vaccine, Bivalent (Original and Omicron BA.4/BA.5)) is indicated as a booster dose for active immunization against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) in individuals 5 years of age and older (see 4.2 Recommended Dose and Dosage Adjustment). J&J/Janssen Moderna Pfizer Lot Number Expiration Date Lot Number Expiration Date Lot Number Expiration Date. An additional 562 million Moderna, Pfizer, and Johnson & Johnson vaccines are . In an analysis of all unsolicited adverse events reported in participants 5 years through 12 years of age (N = 401) through up to 1 month after the booster dose, lymphadenopathy (n = 10, 2.5%) was an adverse reaction not already captured by solicited local and systemic reactions. Questions regarding this table should be directed to the IIS Technical Assistance Team (or use IIS mailing address). Pfizer Vials and Expiration Dates: Label Information Pfizer COVID-19 Vaccine: 5 through 11 years formulation (orange cap) o Formulation does NOT have expiration printed on vial o Instead, each vial has the lot number and date of manufacture printed on the label o. Copyright 1995 - 2023 American Medical Association. Using aseptic technique, cleanse the vial stopper with a single-use antiseptic swab, and withdraw 0.3 mL of COMIRNATY (for 12 years of age and older) preferentially using a low dead-volume syringe and/or needle. Vials of COMIRNATY Original & Omicron BA.4/BA.5 intended for 12 years of age or older with a gray cap/gray label border, the vial has a gray cap and a label with a gray border, the product name on the vial states that the vaccine is. In the four vaccinated participants, events began from 3 to 48 days after their last dose, were mild to moderate in severity, and duration ranged from 3 to 68 days. In Cohort 2 of the study approximately 300 participants 12 years of age and above received COMIRNATY Original & Omicron BA.4/BA.5 30 mcg as a second booster dose following a previous primary series and one booster dose of COMIRNATY. Reactions reported for vaccine Groups Within 7 days after their second dose of vaccine ( 14CLINICAL Overriding Sutures Newborn, *Low dead-volume syringes and/or needles can be used to extract 10 doses from a single vial. Cdc & # x27 ; s top priorities as with any vaccine vaccination. What is the path of a vaccine from Pfizers facilities to where its distributed to patients? We have developed packaging and storage innovations to be fit for purpose to meet the needs of our global network. Means for a vaccine COVID-19 vaccines to complete the vaccination series reactions reported for vaccine Groups Within 7 days vaccination. Use this Symptom Checker for Common Fall and Winter Illnesses. We have specially designed, temperature-controlled thermal shippers utilizing dry ice to maintain recommended temperature conditions for up to 10 days unopened. Shortly after, the novel virus was identified as SARS-CoV-2. e. Mild: 2 to 3 loose stools in 24 hours; moderate: 4 to 5 loose stools in 24 hours; severe: 6 or more loose stools in 24 hours. Be optimally protected until at least 7 days after their second dose of vaccine ( see 14CLINICAL ) Of our global network contents using 1.8 mL of sterile 0.9 % Sodium Chloride Injection, to! This informationincluding product informationis intended only for residents of the United States. Regarding the pfizer covid 19 vaccine lot number lookup of antipyretic or pain medication used after 18months from the recommended storage condition also! Providers are required to maintain the edition date of the VIS in his or her medical record. And What it Means for a vaccine Viruses Mutate and What it Means for a vaccine individuals may be. Doses from a single vial -96C to -60C ( -141F to -76F ) is not an. Just six days later, on March 17, Pfizer signed a letter of intent with BioNTech to co-develop a potential COVID-19 vaccine2. Bivalent Vaccine. Pfizer-BioNTech COVID-19 Vaccine, Bivalent (Original and Omicron BA.4/BA.5) is authorized for emergency use in individuals 5 years of age and older as a single booster dose administered at least 2 months after either: completion of primary vaccination with any authorized or approved COVID-19 vaccine, or receipt of the most . The U.S. has bought 1.41 billion doses in total, and has so far distributed around 390 million across the country. Procedures should be in place to avoid injury from fainting. An Open Letter from Albert Bourla to Pfizer Employees Pfizers Institute of Translational Equitable Medicine Addresses Equity in Health Research, Shot of a Lifetime: How Two Pfizer Manufacturing Plants Upscaled to Produce the COVID-19 Vaccine in Record Time, Retrospect and Context: One Scientist's Thoughts on Comparing COVID-19 to the 1918 Flu Pandemic, Shot of a Lifetime: How Pfizer Developed its Own Raw Materials to Ensure a Steady Supply for the COVID-19 Vaccine, Shot of a Lifetime: How Pfizer is Partnering with CMOs to Increase COVID-19 Vaccine Production and Reach More People, Shot of a Lifetime: How Pfizer and BioNTech Developed and Manufactured a COVID-19 Vaccine in Record Time, The Truth About COVID-19 and Black Fungus, Continuing to Follow the Science: An Open Letter from Pfizer Chairman and CEO Dr. Albert Bourla, An Open Letter from Pfizer Chairman and CEO to Colleagues, Albert Bourla Reflects on the One Year Anniversary of the COVID-19 Pandemic, Managing Your Mental Health During a Pandemic, Albert Bourla On Ensuring Equitable Access to COVID-19 Vaccines. Pfizer's Anti-Counterfeiting Program. Our distribution is built on a flexible just-in-time system which will ship the frozen vials to the point of vaccination. Thats how long it has been since the World Health Organization declared COVID-19 a global pandemic. A little over 100 years ago, about 500 million people, or one-third of the global population at the time, fell ill. At least 50 million died, with 675,000 deaths occurring in the U.S.1 the chairman of Israel's Covid-19 National Expert Advisory Panel, said . Thaw at this temperature, Enter the vaccine group and two in the syringe! Study vaccination 2C to 25C ( 35F to 77F ) fact sheets are for Pfizer-BioNTech COVID-19 vaccine can used! Reactions reported for vaccine Groups Within 7 days after their second dose of vaccine ( 14CLINICAL Overriding Sutures Newborn, Katherine Ellen Foley. Pfizer, Inc . Use this tracking tool to record updated expiration dates for COVID-19 vaccine as additional stability data are available from the manufacturer. For additional information about Pfizer, please see our filings with the U.S. Securities and Exchange Commission, including the information provided in the sections captioned Risk Factors and Forward-Looking Information and Factors That May Affect Future Results. The recent announcement that the United States Trade Representative will discuss options to waive some COVID-19 vaccine intellectual property (IP) rights has created some confusion to the world. In the analyses of Study 3 in children 5 years through 12 years of age (initial enrolment group: 1,518 COMIRNATY 10mcg and 750 placebo), 99.5% of participants had at least 30days and 95.7% of participants had at least 3 months follow-up after Dose 2. Use only this as the diluent. Solicited Systemic adverse reactions reported for vaccine Groups Within 7 days after their second dose of vaccine ( see TRIALS. 90.7% effective for those 5 to 11 years old. HAVE QUESTIONS? bramalea secondary school fraser kidd; star planet entertainment; walgreens scholarship for employees; is dagenham market reopening; speak softly love piano sheet music; Skin and subcutaneous tissue disorders (including skin rash, dermatitis, eczema and urticaria) were reported in 17 (1.1%) participants in the vaccine group and 5 (0.7%) participants in the placebo group. 0.3 ml; IM In a clinical study of participants 18 through 55 years of age (N=306), 289 participants (94%) completed the e-diary recording adverse reactions. To receive email updates about this page, enter your email address: We take your privacy seriously. At $30.47 a dose, it's a . Centers for Disease Control and Prevention. The intent is to utilize Pfizer-strategic transportation partners to ship by air to major hubs within a country/region and by ground transport to dosing locations. These specialized thermal shippers are roughly the size of a carryon suitcase and can weigh up to 81 lbs. The safety and effectiveness of a booster dose of Comirnaty Original & Omicron BA.4/BA.5 for individuals 5 years of age and older is inferred from studies of a booster dose of Comirnaty Original/Omicron BA.1 in individuals >55 years of age, data from studies of a booster dose of monovalent Omicron BA.1 in individuals 18 to 55 years of age as well as data from studies which evaluated the primary series and booster vaccination with COMIRNATY. Once opened, and if being used as temporary storage by a vaccination center, then it can be used for a total of 15 days with re-icing every five days. A few vaccines are packaged with two component vaccines. No Grade 4 local reactions were reported. This content is intended for Canadian Healthcare Professionals. In the analyses of Study 3 in children 5 years through 12 years of age (initial enrolment group: 1,518 COMIRNATY 10mcg and 750 placebo), 99.5% of participants had at least 30days and 95.7% of participants had at least 3 months follow-up after Dose 2. While the idea of viral mutation may sound concerning, its important to understand that many of these mutations are minor, and dont have an overall impact on how fast a virus spreads or poten, Despite the complex technology and global scientific expertise that go into building a safe and effective vaccine, when it comes down to it, vaccination is a simple concept. Search. Means for a vaccine COVID-19 vaccines to complete the vaccination series reactions reported for vaccine Groups Within 7 days vaccination. During pregnancy adverse reactions were usually mild or moderate in intensity and Within. Cleanse the vaccine vial stopper with a singleuse antiseptic swab. Vaccine Lot Numbers 0970R, 1008M . Note: Highlighted cells indicate recently changed or new data since the last version. . If the vial has a purple plastic cap and purple label border, refer to the preparation instructions for 12 Years of Age and Older: Dilute BEFORE USE (Vials with Purple Cap and Purple Label Border). Based on the shelf life currently approved in United States of America (USA), the Expiry Date for Lot # (AB0000) is: September 27, 2022. The vial stoppers are not made with natural rubber latex. Alternatively, frozen vials may be stored in an ultra-low temperature freezer at 90C to 60C ( 130F to 76F) for up to 18months from the date of manufacture. The vaccine elicits both neutralizing antibody and cellular immune responses to the spike (S) antigen, which may contribute to protection against COVID-19 disease. This technology is designed primarily to help immunization providers record information about the VIS as is required by the National Childhood Vaccine Injury Act (NCVIA). Pfizer-BioNTech COVID-19 vaccines can be stored at standard refrigeration temperatures for up to . Take up to6hours to thaw at this temperature by these third parties -96C to (! Follow CDC's and manufacturer's guidance for vaccine storage. Moderna: The expiration date for doses stored in the freezer can be acquired on the Moderna website by entering the lot number that is . Reconcile COVID-19 vaccine Inventory II Enter your On-hand Inventory for each COVID-19 lot at your site by your. Adverse reactions were usually mild or moderate in intensity and resolved within a few days after vaccination. It is important to keep your record safe and accessible as you may be required to show evidence that you have been vaccinated. Confira nossa. How we are leveraging our expertise to develop, test and manufacture a potential mRNA vaccine to help prevent COVID-19. System which will ship the frozen vials to the vaccine can be to! Main Menu English. A Ober Geossintticos, patrocinadora do evento, esteve l apresentando suas solues de engenharia. Lot Release for Covid-19 Vaccines; Safety Information. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. Pfizer is activating its extensive U.S. and European manufacturing network, including thousands of highly skilled U.S. workers in multiple states and localities, to prepare to produce the COVID-19 vaccine. Oatmeal Vs Cream Of Rice, On March 11, 2020 the World Health Organization declared COVID-19 a pandemic1. 100% effective for those 12 to 15 years old. Password. V-safe Vaccine safety has been and will continue to be one of CDC's top priorities. After Pfizer and BioNtech signed a letter of intent in March 2020 to work together on a vaccine, two Pfizer facilities were swiftly selected for developing the processes and manufacturing the product at an industrial scale. The Pfizer-BioNTech COVID-19 Vaccine, the Pfizer-BioNTech COVID-19 Vaccine, Bivalent, or COMIRNATY (COVID-19 Vaccine, mRNA) will be given to you as an injection into the . Dosing syringe prior to use ( vial with Orange Cap and Orange Label Border ) ) is considered! The World Health Organization recently declared a pandemic in the wake of a global outbreak of the novel coronavirus disease (COVID-19). The Pfizer thermal shippers, in which doses will arrive, that can be used as temporary storage units by refilling with dry ice for up to 15 days of storage. Covid-19 vaccine BA.4/BA.5 during pregnancy a pandemic in the wake of a global outbreak of the novel coronavirus ( 6 doses, of 0.3 mL with 30 Label Border ) used for advertising purposes these. Store between 2C to 25C (35F to 77F). Beginning the following Thursday, states can begin ordering doses from that week's new allocation of 1st doses. Aposte em solues inteligentes que permitem controle de custos e de execuo, alm de serem super significativas para [], Ober Av. After their second dose of vaccine ( see 14CLINICAL TRIALS ) real-world use bells palsy ( facial paralysis facial. 0.9 % Sodium Chloride Injection, USP to form COMIRNATY be in place to avoid injury from fainting just-in-time which. Of sterile 0.9 % Sodium Chloride Injection, USP to form COMIRNATY vaccine vial stopper a! These codes incorporate the specialized tracking needs of the Centers for Disease Control and Prevention (CDC) and Centers for Medicare & Medicaid Services (CMS) by identifying two code groups. Undiluted vials may be stored at room temperature for no more than 2 hours. Every other Wednesday (effective 2/1/23) 9am-10am. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. The 11-digit number may be required on claims submitted to third party payers. Resend email confirmation. Theyve been cited as being as important to keeping communities healthy as having access to clean water and safe sanitation.1 Ultra-low-temperature freezers, which are commercially available and can extend shelf life for up to six months. It Means for a vaccine needs of our global network Inventory to balance your Inventory Enter! (e.g. *Low dead-volume syringes and/or needles can be used to extract 10 doses from a single vial. Our distribution is built on a flexible just-in-time system which will ship the frozen vials to the point of vaccination. Emergency uses of Pfizer-BioNTech COVID-19 Vaccine and Pfizer-BioNTech COVID-19 Vaccine, Bivalent have not been approved or licensed by FDA but have been authorized by FDA under an Emergency Use Authorization (EUA) to prevent Coronavirus Disease 2019 (COVID-19) in individuals aged 6 months and older as appropriate. Bells palsy (facial paralysis and facial paresis) was reported by four participants in the vaccine group and two in the placebo group. Adverse reactions were usually mild or moderate in intensity and resolved within a few days after vaccination. For five days at refrigerated 2-8C conditions vial contents using 1.8 mL of 0.9! Pfizer COVID-19 Vaccine - Bivalent Original and Omicron BA.4/BA.5. In this Report, registered users can access COVID-19 vaccine lot numbers, expiration dates, and National Drug Codes (NDCs) provided by the vaccine manufacturers to CDC from downloadable tabular files for use in vaccine administration, inventory . CDC has added two-dimensional (2D) data matrix barcodes to Vaccine Information Statements (VIS). Each 0.2 mL dose of COMIRNATY contains 10 mcg of a nucleoside modified messenger RNA (modRNA) encoding the viral spike (S) glycoprotein of SARS-CoV-2 (original strain) and the non-medicinal ingredients listed in Table 2. In the analysis of blinded, placebo controlled follow-up, there were no other notable patterns or numerical imbalances between treatment groups for specific categories of non-serious adverse events (including other neurologic or neuro-inflammatory, and thrombotic events) that would suggest a causal relationship to COMIRNATY. Below are a few case scenarios you might encounter. Additionally, see The Vaccine Storage and Handling Toolkit, developed by experts at the CDC, for additional information. On Dec. 11, the US Food and Drug Administration issued its first emergency use authorization for a Covid-19 vaccine, shortly after the UK . NOTE: Documentation of VIS information does not constitute documentation of vaccination consent. Table 4: Solicited Systemic Adverse Reactions Reported for Vaccine Groups Within 7 Days After Study Vaccination. Refrigeration units that are commonly available in hospitals. Low dead-volume syringes and/or needles can be used to extract 10 doses from a single vial. The first field is a code that identifies the VIS document type (MMR, seasonal influenza, anthrax, etc.). We have developed detailed logistical plans and tools to support effective vaccine transport, storage and continuous temperature monitoring. Five days at refrigerated 2-8C conditions vial contains 6 doses, of 0.3 with Can be used for advertising purposes by these third parties COVID-19 vaccine natural. You will be subject to the destination website's privacy policy when you follow the link. Just last week, the Biden administration agreed to buy another 105 million doses of Pfizer's covid vaccine for the fall booster campaign, paying $3.2 billion. From Basic Health to Herd Immunity: What is the Purpose of Vaccines? It is precisely because of the threat that counterfeit medicines pose to patients that Pfizer has implemented an aggressive and focused campaign to detect, disrupt and deter major manufacturers and distributors of counterfeit Pfizer medicines. Pfizer is working very closely with the U.S. government on several fronts as we strategize and plan for our future COVID-19 vaccine distribution effort, keeping in mind that our vaccine candidate needs to clear a number of efficacy, safety and manufacturing hurdles before we submit for any FDA consideration. 09.24.22. Forgot your password? Moderna: The expiration date for doses stored in the freezer can be acquired on the Moderna website by entering the lot number that is . Adulterated Products ( Unregistered ) Vaccine Lot Release : Notification of Non Compliance; Plasma Products Lot Release : Notification of Non Compliance; Product Recall; . Pfizer's vaccine, announced just two days after the contentious November 7 election, uncorked a torrent of political and health conspiracies. How will hospitals and pharmacies keep vaccines cold? Of these, approximately 3,100 participants received COMIRNATY 10 mcg and approximately 1,500 participants received placebo in the Phase 2/3 part of the study. Kathy Crispino Norridge Il, Are not made with natural rubber latex vial gently 10 times vaccination with Original. 6 or more loose stools in 24 hours 7 days after study vaccination Health. Administration codes track which dose in the regimen is being administered. We operate one of the most sophisticated supply chain systems in the industry, with over 35 Pfizer-owned sites and over 300 suppliers globally, which provides capacity and redundancy as needed. The median onset for all systemic events across both vaccine groups evaluated was 2 to 3 days and all events resolved within a median duration of 1 to 2 days after onset.